The design features Perugino's portrait and a detail of his "Baptism" fresco from the Sistine Chapel. The inscriptions read 'CITTÀ DEL VATICANO' at the top and 'PERUGINO' above the dates '1523◦2023' at the bottom, with the mintmark 'R' at the left. The outer ring depicts the 12 stars of the European flag.
A Western Europe map spans the coin's right side, with "2 EURO" overlaid—the "2" in the Atlantic. Twelve stars flank the map, six above and six below, connected by six vertical stripes across the inner core.